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  1. No Access

    Article

    Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

    The canonical biological function of selenium is in the production of selenocysteine residues of selenoproteins, and this forms the basis for its role as an essential antioxidant and cytoprotective micronutrie...

    Namgyu Lee, Sung ** Park, Mike Lange, Tenzin Tseyang, Mihir B. Doshi… in Nature Metabolism (2024)

  2. Article

    Open Access

    Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma

    Lipids are a structurally diverse class of biomolecules which can undergo a variety of chemical modifications. Among them, lipid (per)oxidation attracts most of the attention due to its significance in the reg...

    Angela Criscuolo, Palina Nepachalovich… in Nature Communications (2022)

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  3. Article

    Open Access

    Evaluation of lipid quantification accuracy using HILIC and RPLC MS on the example of NIST® SRM® 1950 metabolites in human plasma

    Lipidomics analysis for large-scale studies aiming at the identification and quantification of natural lipidomes is often performed using LC–MS-based data acquisition. However, the choice of suitable LC–MS met...

    Mike Lange, Maria Fedorova in Analytical and Bioanalytical Chemistry (2020)

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  4. No Access

    Article

    Liquid Chromatography Techniques in Lipidomics Research

    Lipids represent a very diverse group of compounds with a high variety of physicochemical properties determining their functional activities. For omics-wide identification of lipid species from complex biologi...

    Mike Lange, Zhixu Ni, Angela Criscuolo, Maria Fedorova in Chromatographia (2019)