7 Result(s)
within
Mika Kivimäki
Biomedicine
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Article
Open AccessThe association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study
Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer’s disease. Beyond its association with late...
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Article
Open AccessExploring variability in basal ganglia connectivity with functional MRI in healthy aging
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving...
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Article
Open AccessLong working hours and cancer risk: a multi-cohort study
Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.
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Article
Open AccessModifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies
With drug treatment for dementia being of limited effectiveness, the role of primary prevention, in particular the predictive value of modifiable cardiovascular disease risk factors, may warrant exploration. T...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
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Article
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Ruth Loos and colleagues use genome-wide association to identify common variants influencing body fat percentage. Unexpectedly, they show that a body-fat–decreasing allele near IRS1 is associated with an impaired...
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Article
Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study
The determinants of prostate cancer––aside from established but non-modifiable risk factors of increased age, black ethnicity, and a positive family history––are poorly understood.
