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  1. Article

    Open Access

    A generic approach to identify Transcription Factor-specific operator motifs; Inferences for LacI-family mediated regulation in Lactobacillus plantarum WCFS1

    A key problem in the sequence-based reconstruction of regulatory networks in bacteria is the lack of specificity in operator predictions. The problem is especially prominent in the identification of transcript...

    Christof Francke, Robert Kerkhoven, Michiel Wels, Roland J Siezen in BMC Genomics (2008)

  2. Article

    Open Access

    An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes, with emphasis on prediction of substrate specificity of transporters

    T-box anti-termination is an elegant and sensitive mechanism by which many bacteria maintain constant levels of amino acid-charged tRNAs. The amino acid specificity of the regulatory element is related to a so...

    Michiel Wels, Tom Groot Kormelink, Michiel Kleerebezem, Roland J Siezen in BMC Genomics (2008)

  3. Article

    Open Access

    LAB-Secretome: a genome-scale comparative analysis of the predicted extracellular and surface-associated proteins of Lactic Acid Bacteria

    In Lactic Acid Bacteria (LAB), the extracellular and surface-associated proteins can be involved in processes such as cell wall metabolism, degradation and uptake of nutrients, communication and binding to sub...

    Miaomiao Zhou, Daniel Theunissen, Michiel Wels, Roland J Siezen in BMC Genomics (2010)

  4. Article

    Open Access

    Detection and classification of the integrative conjugative elements of Lactococcus lactis

    Lactococcus lactis is widely applied by the dairy industry for the fermentation of milk into products such as cheese. Adaptation of L. lactis to the dairy environment often depends on functions encoded by mobile...

    Simon van der Els, Reshtrie Sheombarsing, Thijn van Kempen, Michiel Wels in BMC Genomics (2024)