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Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

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  1. Article

    Open Access

    The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

    Aberrant immune responses including reactive phagocytes are implicated in the etiology of age-related macular degeneration (AMD), a major cause of blindness in the elderly. The translocator protein (18 kDa) (T...

    Anne Wolf, Marc Herb, Michael Schramm, Thomas Langmann in Nature Communications (2020)

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  2. Article

    Open Access

    Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

    Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that...

    Jessica Gräb, Isabelle Suárez, Edeltraud van Gumpel, Sandra Winter… in Nature Communications (2019)

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