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    Open Access

    Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset

    The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG repeat length but modified by other genes. In this study, we used exome sequencing of 683 patients with HD with extremes of ons...

    Branduff McAllister, Jasmine Donaldson, Caroline S. Binda… in Nature Neuroscience (2022)

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