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Article
Open AccessComparison of an automatic analysis and a manual analysis of conjunctival microcirculation in a sheep model of haemorrhagic shock
Life-threatening diseases of critically ill patients are known to derange microcirculation. Automatic analysis of microcirculation would provide a bedside diagnostic tool for microcirculatory disorders and all...
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Article
Open AccessComparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock
The Surviving Sepsis Guidelines suggest the use of vasopressin in case of catecholamine-refractory septic shock. Terlipressin (TP) as a V1-selective AVP analogue is a potential alternative, though data regarding ...
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Article
Open AccessFeasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock
This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of ...
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Article
Open AccessHigh-fidelity is not superior to low-fidelity simulation but leads to overconfidence in medical students
Simulation has become integral to the training of both undergraduate medical students and medical professionals. Due to the increasing degree of realism and range of features, the latest mannequins are referre...
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Article
Open AccessAssociation of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to...
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Article
Open AccessOptical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study
Microcirculatory disorders are crucial in pathophysiology of organ dysfunction in critical illness. Evaluation of sublingual microcirculation is not routinely conducted in daily practice due to time-consuming ...
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Article
Open AccessAuthor Correction: Optical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessLong term follow-up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs
Pancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency (EPI). This allows the study of digestive processes and pancreatic enzyme replacement therapies. However, detailed descrip...
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Article
Open AccessA model of porcine polymicrobial septic shock
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models ha...
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Article
Open AccessFlipped Classroom: Improved team performance during resuscitation training through interactive pre-course content – a cluster-randomised controlled study
Resuscitation is a team effort, and it is increasingly acknowledged that team cooperation requires training. Staff shortages in many healthcare systems worldwide, as well as recent pandemic restrictions, limit...
