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  1. Article

    Open Access

    A model of porcine polymicrobial septic shock

    Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models ha...

    Finnja Marie Zurek-Leffers, Florian Lehmann in Intensive Care Medicine Experimental (2023)

  2. Article

    Open Access

    Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis

    The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to...

    Alexandros Rovas, Laura Mareen Seidel, Hans Vink, Timo Pohlkötter in Critical Care (2019)

  3. Article

    Open Access

    Feasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock

    This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of ...

    Maged Alnawaiseh, Christian Ertmer, Laura Seidel, Philip Helge Arnemann in Critical Care (2018)

  4. Article

    Open Access

    Comparison of an automatic analysis and a manual analysis of conjunctival microcirculation in a sheep model of haemorrhagic shock

    Life-threatening diseases of critically ill patients are known to derange microcirculation. Automatic analysis of microcirculation would provide a bedside diagnostic tool for microcirculatory disorders and all...

    Philip-Helge Arnemann, Michael Hessler in Intensive Care Medicine Experimental (2016)