-
Article
Open AccessA model of porcine polymicrobial septic shock
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models ha...
-
Article
Open AccessLong term follow-up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs
Pancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency (EPI). This allows the study of digestive processes and pancreatic enzyme replacement therapies. However, detailed descrip...
-
Article
Open AccessAssociation of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to...
-
Article
Open AccessFeasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock
This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of ...
-
Article
Open AccessComparison of an automatic analysis and a manual analysis of conjunctival microcirculation in a sheep model of haemorrhagic shock
Life-threatening diseases of critically ill patients are known to derange microcirculation. Automatic analysis of microcirculation would provide a bedside diagnostic tool for microcirculatory disorders and all...