116 Result(s)

Article

BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC

An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contrib...

Sikai Wang, Hongxia Cheng, Miaomiao Li, Dongmei Gao, Haoran Wu… in Cell Death & Disease (2024)

Article

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM o...

Shuo Wang, Huiyan Li, **ong Liu, Tingting Yin, Tingru Li… in Cell Death & Disease (2024)

Article

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, necessitating the identification of novel therapeutic targets. Lysosome Associated Protein Transmembrane 4B (LAPTM4B) i...

Ruyu Yan, Dan Liu, Hongjuan Guo, Minxia Liu, Dong** Lv… in Cell Death & Disease (2024)

Article

The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1

There is growing evidence indicating that deubiquitinating enzymes may contribute to tumor progression and can serve as promising therapeutic targets.

Miaomiao Yang, Yujie Wei, **n He, Changwei **a in Biology Direct (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding

Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the gene regulatory networks governing wound healing remain poorly understood. Here, employing single-worm RNA sequencing...

**nghai Yu, **ghua Zhou, Wenkai Ye, **gxiu Xu, Rui Li, Li Huang… in Communications Biology (2024)

Article

Discovery and engineering of Tsp2Cas9 for genome editing

Huilin Mao, Yuwen Tian, Ziwen Wang, **gtong Liu, **g**g Wei, Yao Wang… in Cell Discovery (2024)

Article

Aberrant splicing of Ca_V1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia

Diabetic hyperglycemia induces dysfunctions of arterial smooth muscle, leading to diabetic vascular complications. The Ca_V1.2 calcium channel is one primary pathway for Ca²⁺ influx, which initiates vasoconstricti...

Wei Hou, Shumin Yin, Pengpeng Li, Ludan Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Phylogeny and expression patterns of ERF genes that are potential reproductive inducers in hybrid larch

Larch is an important component of northern forests and a major cultivated tree species in restoration of forest cover using improved seed material. In recent years, the continuous low seed production has seve...

Junfei Hao, Daixi Xu, Chen Wang, Qing Cao, Qingrong Zhao, Miaomiao **e… in BMC Genomics (2024)

Article

Phenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction

Phenolic compounds are industrially versatile chemicals, also the most ubiquitous pollutants. Recently, biosynthesis and biodegradation of phenols has attracted increasing attention, while phenols’ toxicity is...

**nyue Sui, Jichao Wang, Zhiqiang Zhao, Bin Liu, Miaomiao Liu… in Communications Biology (2024)

Article

Single-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis

Cervical cancer (CC) is a common gynecological malignancy. Despite the current screening methods have been proved effectively and significantly decreased CC morbidity and mortality, deficiencies still exist. S...

Bo Sheng, Shuya Pan, Miaomiao Ye, He**g Liu, Jiamin Zhang, Bo Zhao… in Cell Death & Disease (2024)

Article

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer

The gas therapy is drawing increasing attention in the treatment of many diseases including cancer. As one of gas signaling molecules, carbon monoxide (CO) has been proved to exert anti-cancer effects via trigger...

Wei Cao, Mingyu Sun, K. N. Yu, Lele Zhao, Yue Feng, Chunhua Tan… in Cell Death Discovery (2024)

Article

Time series single-cell transcriptional atlases reveal cell fate differentiation driven by light in Arabidopsis seedlings

Light serves as the energy source for plants as well as a signal for growth and development during their whole life cycle. Seedling de-etiolation is the most dramatic manifestation of light-regulated plant dev...

Xue Han, Yilin Zhang, Zhiying Lou, Jian Li, Zheng Wang, Chunlei Gao… in Nature Plants (2023)

Article

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is characterized by aberrant myofibroblast activation and patholo...

Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li… in Cell Death Discovery (2023)

Article

Nuclear lncRNA NORSF reduces E2 release in granulosa cells by sponging the endogenous small activating RNA miR-339

Functioning as a competing endogenous RNA (ceRNA) is the main action mechanism of most cytoplasmic lncRNAs. However, it is not known whether this mechanism of action also exists in the nucleus.

Miaomiao Wang, Yang Wang, Liu Yang, **ng Du, Qifa Li in BMC Biology (2023)

Article

The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer

Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, w...

Weiyu Dai, Linjie Hong, Wushuang **ao, Luyu Zhang, Weihong Sha… in Communications Biology (2023)