26 Result(s)

Article

BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC

An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contrib...

Sikai Wang, Hongxia Cheng, Miaomiao Li, Dongmei Gao, Haoran Wu… in Cell Death & Disease (2024)

Article

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM o...

Shuo Wang, Huiyan Li, **ong Liu, Tingting Yin, Tingru Li… in Cell Death & Disease (2024)

Article

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, necessitating the identification of novel therapeutic targets. Lysosome Associated Protein Transmembrane 4B (LAPTM4B) i...

Ruyu Yan, Dan Liu, Hongjuan Guo, Minxia Liu, Dong** Lv… in Cell Death & Disease (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

Discovery and engineering of Tsp2Cas9 for genome editing

Huilin Mao, Yuwen Tian, Ziwen Wang, **gtong Liu, **g**g Wei, Yao Wang… in Cell Discovery (2024)

Article

Single-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis

Cervical cancer (CC) is a common gynecological malignancy. Despite the current screening methods have been proved effectively and significantly decreased CC morbidity and mortality, deficiencies still exist. S...

Bo Sheng, Shuya Pan, Miaomiao Ye, He**g Liu, Jiamin Zhang, Bo Zhao… in Cell Death & Disease (2024)

Article

Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion

Bromodomain-containing protein 4 (BRD4), the major component of bromodomain and extra-terminal domain (BET) protein family, has important functions in early embryonic development and cancer development. Howeve...

Yi Liu, He**g Liu, Miaomiao Ye, Mengying Jiang, **n Chen… in Cell Death & Disease (2023)

Article

The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation

Long non-coding RNAs (lncRNAs) have been functionally characterised in various diseases. LncRNA PAX-interacting protein 1-antisense RNA 1 (PAXIP1-AS1) has reportedly been associated with cancer development. Ho...

Jiaying Li, Miaomiao Pei, Wushuang **ao, Xuehua Liu, Linjie Hong… in Cell Death & Disease (2023)

Article

COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism

COX7A1, a subunit of cytochrome c oxidase, holds an important position in the super-assembly which integrates into multi-unit heteromeric complexes peripherally in the mitochondrial electron transport chain (E...

Yetong Feng, Jiayi Xu, Mengjiao Shi, Rongrong Liu, Lei Zhao… in Cell Death & Disease (2022)

Article

Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC

The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the progression of various tumors, emerging as a potential therapeutic target. This study aimed to determine the role of USP1 as...

Longhao Wang, Tao Hu, Zhibo Shen, Yuanyuan Zheng, Qishun Geng… in Cell Death & Disease (2022)

Article

Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells

**aorui Yang, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang… in Cell Death & Disease (2022)

Article

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding of immunopathy. While the detrimental effects of STING during sepsis had been well documented, the exact me...

Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li… in Cell Death & Disease (2022)

Article

ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis

A disintegrin and metalloprotease-10(ADAM10) promotes the metastasis of prostate cancer (PCa), but the specific mechanism is indistinct. Herein, DU145 cell lines with stable overexpression and knockdown of ADA...

Chenchen Cai, Miaomiao Zhang, Lei Liu, Haoliang Zhang, Yi Guo… in Cell Death & Disease (2022)

Article

Correction: The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression

Yangyang Guo, Hengyue Zhu, Yanyi **ao, Hangcheng Guo, Miaomiao Lin… in Cell Death & Disease (2022)

Article

TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis

Tumor necrosis factor-α-induced protein 8 (TNFAIP8 or TIPE) is a member of the TNFAIP8 family. While TIPE was broadly considered to be pro-cancerous, its precise roles in carcinogenesis especially those of the...

Yunwei Lou, Xueqin Tian, Chen Sun, Miaomiao Song, Meijuan Han… in Cell Death & Disease (2022)

Article

IL-1β-activated mTORC2 promotes accumulation of IFN-γ⁺ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Liver fibrosis represents a severe stage of liver damage, with hallmarks of inflammation, hepatic stellate cell activation, and extracellular matrix accumulation. Although previous studies demonstrated γδ T ce...

Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu… in Cell Death & Disease (2022)

Article

The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression

Niclosamide, a cell-permeable salicylanilide, was approved by the Food and Drug Administration for its anthelmintic efficiency. A growing body of evidence in recent years suggests that niclosamide exhibits pot...

Yangyang Guo, Hengyue Zhu, Yanyi **ao, Hangcheng Guo, Miaomiao Lin… in Cell Death & Disease (2022)

Article

Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of β cell identity genes

Short-chain fatty acids (SCFAs) produced by the gut microbiota have been well demonstrated to improve metabolic homeostasis. However, the role of SCFAs in islet function remains controversial. In the present s...

Shushu Wang, Miaomiao Yuan, Linlin Zhang, Kecheng Zhu… in Cell Death & Disease (2022)

Article

USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation

As an important regulator of intracellular protein degradation, the mechanism of the deubiquitinating enzyme family in tumour metastasis has received increasing attention. Our previous study revealed that USP3...

**aosheng Wu, Hao Wang, Dan** Zhu, Yixia Chai, **g Wang… in Cell Death & Disease (2021)

Article

Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis

Acinar cell injury and the inflammatory response are critical bioprocesses of acute pancreatitis (AP). We investigated the role and underlying mechanism of sulfiredoxin-1 (Srxn1) in AP. Mild AP was induced by ...

Jun He, Miaomiao Ma, Daming Li, Kunpeng Wang, Qiuguo Wang… in Cell Death & Disease (2021)