18 Result(s)
within
Menglong Li
Chemistry
English
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Article
Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway
Blood-brain barrier breakdown and ROS overproduction are important events during the progression of ischemic stroke aggravating brain damage. Geraniol, a natural monoterpenoid, possesses anti-apoptotic, cytopr...
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Article
Thermal behavior and thermal stabilization of guanidine hydrochloride-modified acrylic fiber for preparation of low-cost carbon fiber
A commercial textile-grade acrylic fiber was modified with guanidine hydrochloride for the preparation of low-cost carbon fibers. Thermal behavior of the modified acrylic fiber was studied by simultaneous diff...
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Article
Individually double minimum-distance definition of protein–RNA binding residues and application to structure-based prediction
Identifying protein–RNA binding residues is essential for understanding the mechanism of protein–RNA interactions. So far, rigid distance thresholds are commonly used to define protein–RNA binding residues. Ho...
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Article
Effective prediction of bacterial type IV secreted effectors by combined features of both C-termini and N-termini
Various bacterial pathogens can deliver their secreted substrates also called as effectors through type IV secretion systems (T4SSs) into host cells and cause diseases. Since T4SS secreted effectors (T4SEs) pl...
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Article
A comparative study of family-specific protein–ligand complex affinity prediction based on random forest approach
The assessment of binding affinity between ligands and the target proteins plays an essential role in drug discovery and design process. As an alternative to widely used scoring approaches, machine learning me...
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Article
A functional feature analysis on diverse protein–protein interactions: application for the prediction of binding affinity
Protein–protein interactions (PPIs) play crucial roles in diverse cellular processes. There are different types of PPIs based on the composition, affinity and whether the association is permanent or transient....
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Article
Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media
In this work, we used molecular dynamic (MD) simulation to study trypsin with and without a six-amino-acid peptide bound in three different solvents (water, acetonitrile and hexane) in order to provide molecul...
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Article
Effects of water content on the tetrahedral intermediate of chymotrypsin - trifluoromethylketone in polar and non-polar media: observations from molecular dynamics simulation
The work uses MD simulation to study effects of five water contents (3 %, 10 %, 20 %, 50 %, 100 % v/v) on the tetrahedral intermediate of chymotrypsin - trifluoromethyl ketone in polar acetonitrile and non-pol...
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Article
Effects of the position and manner of hydration on the stability of solvated N-methylacetamides and the strength of binding between N-methylacetamide and water clusters: a computational study
This work mainly studies the effects of the position (there are two possible hydrated sites) and the manner (i.e., whether water acts as a proton donor or acceptor) of hydration by various numbers of water mol...
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Article
Prediction of Lipid-Binding Sites Based on Support Vector Machine and Position Specific Scoring Matrix
Lipid–protein interactions play a vital role in various biological processes, which are involved in cellular functions and can affect the stability, folding and the function of peptides and proteins. In this s...
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Article
Prediction of Beta-Turn in Protein Using E-SSpred and Support Vector Machine
β-Turn is a secondary protein structure type that plays an important role in protein configuration and function. Here, we introduced an approach of β-turn prediction that used the support vector machine (SVM) ...
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Article
An ensemble method based on a self-organizing map for near-infrared spectral calibration of complex beverage samples
Based on a so-called ensemble strategy, an algorithm is proposed for near-infrared (NIR) spectral calibration of complex beverage samples. This algorithm is a combination of a novel training set/test set sampl...
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Article
Random Subspace Regression Ensemble for Near-Infrared Spectroscopic Calibration of Tobacco Samples
An ensemble, a model-independent technique based on combining several models for classification/regression tasks, allows us to achieve a high accuracy that is often not achievable with single models. Such comb...
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Article
Study of the feasibility of distinguishing cigarettes of different brands using an Adaboost algorithm and near-infrared spectroscopy
The feasibility of utilizing an Adaboost algorithm in conjuction with near-infrared (NIR) spectroscopy to automatically distinguish cigarettes of different brands was explored. Simple linear discriminant analy...
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Article
Predicting cis/trans Structure of Alkene Based on Infrared Spectra
The application of chemometrics to analyze the information of the cis/trans structure of alkenes in infrared spectra (IR) is introduced. For data from the OMNIC IR spectral database, two feature selection methods...
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Article
Calibration Transfer between Two Near-Infrared Spectrometers Based on a Wavelet Packet Transform
A standardization algorithm, called WPTS, which is based on a wavelet packet transform (WPT) and entropy criteria, is proposed to transfer spectra between two near-infrared spectrometers. First, the spectra of...
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Article
Prediction of Mitochondrial Proteins Using Discrete Wavelet Transform
A new method was proposed for prediction of mitochondrial proteins by the discrete wavelet transform, based on the sequence–scale similarity measurement. This sequence–scale similarity, revealing more informat...
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Article
Detection of oncoprotein platelet-derived growth factor using a fluorescent signaling complex of an aptamer and TOTO
There have recently been advances in the application of aptamers, a new class of nucleic acids that bind specifically with target proteins, as protein recognition probes for biomedical study. The development o...
