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Article
Effect of mold and core preheating temperature on corrosion resistance of casting Al-12Si alloy U-shaped cooling channel
Temperature has an important impact on the corrosion resistance of mold with cooling channels prepared by casting method. The effect of preheating temperature of the mold and the carbon fiber core on the rough...
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Article
Open AccessPost-translational modification of Parkin and its research progress in cancer
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of...
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Article
Open AccessCombining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for t...
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Article
Open AccessReal-Time Vital Mineralization Detection and Quantification during In Vitro Osteoblast Differentiation
In vitro studies of osteoblasts traditionally use Alizarin Red as a golden standard for the detection and quantification of mineralization, which is a marker of osteoblast differentiation. However, this method...
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Article
Open AccessIntratumoral treatment of one tumor lesion with LTX-315 induces complete tumor regression and long-term specific protective immune responses in a metastatic rodent tumor model
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Article
Open AccessOsteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling
Bone metastases in prostate cancer are predominantly osteoblastic. To study regulatory mechanisms underlying the establishment of prostate cancer within an osteoblastic microenvironment, human androgen-sensiti...
