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  1. No Access

    Article

    Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice

    Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency of ETs metabolism to UroA in humans depends on gut microbiot...

    Meng-yun Xu, **g-**g Xu, Li-**g Kang, Zheng-hong Liu… in Acta Pharmacologica Sinica (2024)

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    Article

    Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers in the world. The therapeutic outlook for HCC patients has significantly improved with the advent and development of systematic and t...

    Fan Yang, Lin Jia, Hong-chao Zhou, **g-nan Huang… in Acta Pharmacologica Sinica (2024)

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    Article

    Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice

    Diabetic patients frequently experience neuropathic pain, which currently lacks effective treatments. The mechanisms underlying diabetic neuropathic pain remain unclear. The anterior cingulate cortex (ACC) is ...

    Zi-hua Song, **ang-Jie Song, Chen-ling Yang, Peng Cao, Yu Mao… in Acta Pharmacologica Sinica (2023)