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Article
Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy
Cytochrome P450 (CYP) 2C9 catalyzes the biotransformation of indomethacin to its inactive metabolite O-desmethylindomethacin (DMI). The aim of this work was to determine the effect of CYP2C9 polymorphisms on indo...
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Article
Towards learning a semantic-consistent subspace for cross-modal retrieval
A great many of approaches have been developed for cross-modal retrieval, among which subspace learning based ones dominate the landscape. Concerning whether using the semantic label information or not, subspa...
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Chapter and Conference Paper
Unsupervised Multi-view Subspace Learning via Maximizing Dependence
The recent years have witnessed the great significance of learning from multi-view data in real-world tasks, such as clustering, classification and retrieval. In this paper, we propose an unsupervised dependen...
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Article
MGMT DNA repair gene promoter/enhancer haplotypes alter transcription factor binding and gene expression
The O6-methylguanine-DNA methyltransferase (MGMT) protein removes O6-alkyl-guanine adducts from DNA. MGMT expression can thus alter the sensitivity of cells and tissues to environmental and chemotherapeutic alkyl...
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Article
Social video annotation by combining features with a tri-adaptation approach
Online social video websites such as YouTube allow users to manually annotate their video documents with textual labels. These labels can be used as indexing keywords to facilitate search and organization of v...
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Chapter and Conference Paper
Robust Multi-label Image Classification with Semi-Supervised Learning and Active Learning
Most existing work on multi-label learning focused on supervised learning which requires manual annotation samples that is labor-intensive, time-consuming and costly. To address such a problem, we present a no...
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Protocol
Single-Molecule Force Spectroscopy of Polycystic Kidney Disease Proteins
Atomic force microscopy in its single-molecule force spectroscopy mode is a nanomanipulation technique that is extensively used for the study of the mechanical properties of proteins. It is particularly suited...
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Article
Isolation and characterization of alkane hydroxylases from a metagenomic library of Pacific deep-sea sediment
Two clones 9E7 and 21G8 in a metagenomic library of the east Pacific deep-sea sediment were found to contain alkane hydroxylase genes (alkB). The whole insert sequences of the two cosmid clones were determined. T...
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Article
Microbial Diversity at a Deep-Sea Station of the Pacific Nodule Province
The Pacific nodule province covers about 4.5 million km2 in the eastern tropical Pacific with abundance of polymetallic nodules. Microbes are believed to play large roles in the metal cycling in many environments...