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  1. Article

    A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial–mesenchymal transition

    Cathepsin L (CTSL), a cysteine protease, is closely related to tumor occurrence, development, and metastasis, and possibly regulates cancer cell resistance to chemotherapy. miRNAs, especially the miR-200 famil...

    Yi-fan Zhao, Mei-ling Han, Ya-jie **ong, Long Wang, Yao Fei… in Acta Pharmacologica Sinica (2018)

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  2. Article

    Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells

    Cathepsin L (CTSL), a lysosomal acid cysteine protease, is known to play important roles in tumor metastasis and chemotherapy resistance. In this study we investigated the molecular mechanisms underlying the r...

    Mei-ling Han, Yi-fan Zhao, Cai-hong Tan, Ya-jie **ong… in Acta Pharmacologica Sinica (2016)

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