11 Result(s)
within
Massimiliano Cazzaniga
-
Article
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
The use of tamoxifen as a preventive agent may be limited by the increased risk of endometrial cancer and venous thromboembolic events observed in postmenopausal women. We have recently shown a comparable acti...
-
Article
Breast Cancer Prevention Trials Using Retinoids
Retinoids have been studied as chemopreventive agents in clinical trials. Given their ability to inhibit mammary carcinogenesis in preclinical models. Fenretinide has extensively been investigated because of i...
-
Article
Effects of raloxifene on sex steroid hormones and C-telopeptide in postmenopausal women with primary breast cancer
Within a multicentric, double-blind, placebo-controlled phase II trial, postmenopausal women with primary breast cancer were randomized to either 60 or 600 mg daily of raloxifene or placebo administered for 2 ...
-
Article
Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis
Several independent studies have presented evidence for the involvement of human papillomaviruses (HPV) in the aetiology of human breast cancer, while others have reported the opposite findings. Here, we have ...
-
Article
Open AccessBreast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo
Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no s...
-
Article
Open AccessA randomized phase II presurgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with estrogen receptor-positive breast cancer
We previously demonstrated that 1 or 5 mg per day of tamoxifen (T) given for four weeks before surgery reduces Ki-67 in breast cancer (BC) patients to the same extent as the standard 20 mg/d. Given the long ha...
-
Article
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide
Tamoxifen and fenretinide have been extensively studied and exhibit breast cancer-preventing activity. We aimed to assess their effect on sex hormones, sex hormone binding globulin (SHBG) and retinol, and thei...
-
Article
Open AccessDifferential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial
Treatment of diabetics with metformin is associated with decreased breast cancer risk in observational studies, but it remains unclear if this drug has clinical antineoplastic activity. In a recent presurgical...
-
Chapter
Chemoprevention
Over the past three decades, great efforts have been made to seek cancer chemoprevention strategies. Although the precise mechanisms promoting breast cancer are not completely established, thanks to increasing...
-
Chapter and Conference Paper
Exploring Context-Aware Activities to Enhance the Learning Experience
Mobile geolocation applications have been growing in popularity in the last decade. The ability to run a service on a mobile device that provides facts or recreational information to users opens up new opport...
-
Chapter
A Soft Option for Primary Prevention: Drugs and Agents
High-risk subjects due to an inherited germline genetic mutation in one or both tumor suppressor genes named BRCA1 and BRCA2 have usually a couple of strategies for risk reduction which are rather different among...
