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  1. Article

    Open Access

    Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

    Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and ...

    Kazuhiro Kurosawa, Tatsuro Misu, Yoshiki Takai… in Acta Neuropathologica Communications (2015)

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  2. Article

    Open Access

    Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

    Neuromyelitis optica (NMO) is an autoimmune disease targeting aquaporin 4 (AQP4), localized mainly at the astrocytic foot processes. Loss of AQP4 and glial fibrillary acidic protein (GFAP) was reported, but th...

    Tatsuro Misu, Romana Höftberger, Kazuo Fujihara, Isabella Wimmer… in Acta Neuropathologica (2013)

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    Article

    Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

    Hidefumi Ito, Kengo Fujita, Masataka Nakamura, Reika Wate… in Acta Neuropathologica (2011)

  4. No Access

    Article

    Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models

    Peroxiredoxin-ll (Prxll) and glutathione peroxidase-l (GPxl) are regulators of the redox system that is one of the most crucial supporting systems in neurons. This system is an antioxidant enzyme defense syste...

    Shinsuke Kato, Masako Kato, Yasuko Abe, Tomohiro Matsumura… in Acta Neuropathologica (2005)

  5. No Access

    Article

    Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models

    Living cells produce reactive oxygen species (ROSs). To protect themselves from these ROSs, the cells have developed both an antioxidant system containing superoxide dismutase 1 (SOD1) and a redox system inclu...

    Shinsuke Kato, Yusuke Saeki, Masashi Aoki, Makiko Nagai… in Acta Neuropathologica (2004)

  6. No Access

    Article

    Miyoshi myopathy patients with novel 5' splicing donor site mutations showed different dysferlin immunostaining at the sarcolemma

    We analyzed five clinically defined cases of Miyoshi myopathy both genetically and immunologically. Western blot of muscle specimens confirmed that all of these patients had dysferlin deficiency. Immunohistoc...

    Akiko Saito, Itsuro Higuchi, Masanori Nakagawa, Mineki Saito… in Acta Neuropathologica (2002)