3 Result(s)
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Masashi Aoki
Molecular Medicine
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Article
Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease for which no effective treatment is available, despite decades of research into SOD1-mutant familial ALS (FALS). The majority of ALS pat...
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Article
Open AccessSuppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighbor...
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Article
Clinical manifestations in patients with SOS1 mutations range from Noonan syndrome to CFC syndrome
Noonan syndrome (NS) and cardio-facio-cutaneous (CFC) syndrome are autosomal dominant disorders characterized by heart defects, facial dysmorphism, ectodermal abnormalities, and mental retardation. There is a...
