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Masahiko Ajiro
Proteomics
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Article
Open AccessPDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing
Deep-intronic variants that alter RNA splicing were ineffectively evaluated in the search for the cause of genetic diseases. Determination of such pathogenic variants from a vast number of deep-intronic varian...
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Article
Open AccessVemurafenib-resistant BRAF selects alternative branch points different from its wild-type BRAF in intron 8 for RNA splicing
One mechanism of resistance of the melanoma-associated BRAF kinase to its small molecule inhibitor vemurafenib is by point mutations in its intron 8 resulting in exons 4–8 skip**. In this report, we carried ...
