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  1. No Access

    Article

    Development and pilot testing of a leaflet informing women with breast cancer about genomic testing for polygenic risk

    The inclusion of polygenic risk scores in breast cancer risk prediction models provides a more personalised and accurate prediction of breast cancer risk for women with and without breast cancer, who would oth...

    Rajneesh Kaur, Bettina Meiser, Tatiane Yanes, Mary-Anne Young… in Familial Cancer (2019)

  2. No Access

    Article

    Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?

    Germline TP53 mutation carriers are at high risk of develo** a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutatio...

    Kate A. McBride, Mandy L. Ballinger, Timothy E. Schlub, Mary-Anne Young… in Familial Cancer (2017)

  3. No Access

    Article

    Implementing a telephone based peer support intervention for women with a BRCA1/2 mutation

    Women with a BRCA1/2 gene mutation face complex risk management decisions and communication issues that can lead to increased levels of distress and unmet needs. We describe the implementation of a peer-suppor...

    Ashley Farrelly, Victoria White, Mary-Anne Young, Michael Jefford… in Familial Cancer (2015)

  4. No Access

    Article

    Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features

    Large genomic rearrangements (LGRs) account for at least 10 % of the mutations in BRCA1 and 5 % of BRCA2 mutations in outbred hereditary breast and ovarian cancer (HBOC) families. Data from some series suggest LG...

    Paul A. James, Sarah Sawyer, Samantha Boyle, Mary-Anne Young… in Familial Cancer (2015)

  5. No Access

    Article

    Unmet support needs and distress among women with a BRCA1/2 mutation

    Distress levels among female BRCA1/2 mutation carriers can be similar to levels found among breast cancer patients. While psychological distress has been associated with unmet needs among cancer patients no study...

    Ashley Farrelly, Victoria White, Bettina Meiser, Michael Jefford… in Familial Cancer (2013)

  6. No Access

    Article

    The consequences of risk reducing sal**o-oophorectomy: the case for a coordinated approach to long-term follow up post surgical menopause

    Women with germline mutations in BRCA1 and BRCA2 genes have significantly increased lifetime risks of breast and ovarian cancer. To manage both the ovarian and breast cancer risks the current recommendation is un...

    Carmel Pezaro, Paul James, Joanne McKinley, Mary Shanahan… in Familial Cancer (2012)

  7. No Access

    Article

    Implications for cancer genetics practice of pro-actively assessing family history in a General Practice cohort in North West London

    At present cancer genetics referrals are reactive to individuals asking for a referral and providing a family history thereafter. A previous pilot study in a single General Practice (GP) catchment area in Nort...

    Kelly Kohut, Lucia D’Mello, Elizabeth K. Bancroft, Sarah Thomas… in Familial Cancer (2012)

  8. No Access

    Article

    Screening behavior in women at increased familial risk for breast cancer

    This multicenter study examined the adherence of high-risk women to screening recommendations for breast and ovarian cancer following consultation at a familial cancer clinic (FCC). Self-report questionnaires ...

    Yoland C. Antill, John Reynolds, Mary Anne Young,  ˙ Judy A. Kirk… in Familial Cancer (2006)