55 Result(s)
within
Mary B **a
Internal Medicine
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Article
Correction to: Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial
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Article
Updates in the Pathology and Therapy of BRCA Germline–Associated Breast Cancer with a Focus on HER2 Amplification
Germline pathogenic variants of the breast cancer type 1 or 2 susceptibility genes (BRCA1 or BRCA2) are associated with the majority of hereditary breast and ovarian cancer syndromes (HBOC). The prevalence of hum...
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Article
Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial
Type 2 diabetes in people in the healthy weight BMI category (<25 kg/m2), herein defined as ‘normal-weight type 2 diabetes’, is associated with sarcopenia (low muscle mass). Given this unique body composition, th...
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Open AccessOutpatient management of urinary tract infections by medical officers in Nairobi, Kenya: lack of benefit from audit and feedback on adherence to treatment guidelines
Acute uncomplicated urinary tract infections are common in outpatient settings but are not treated optimally. Few studies of the outpatient use of antibiotics for specific diagnoses have been done in sub-Sahar...
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A Multi-Center Evaluation of the Pharmacokinetics and Safety of Intravenous Ibuprofen in Infants 1–6 Months of Age
Enteral ibuprofen was first approved as a prescription drug in 1974 for the US market. An intravenous (IV) ibuprofen formulation is approved for use in children older than 6 months of age, but there are limite...
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Article
Separate But Not Equal? A Cross-Sectional Study of Segregation by Payor Mix in Academic Primary Care Clinics
At some US Academic Health Centers (AHCs), patients with predominantly Medicaid insurance are seen in one clinic and patients with other insurance are seen in another. The extent of this practice and implicati...
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Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states
The association of TSAs with metachronous neoplasms is well established and suggests that TSAs would also have an association with synchronous neoplasms.
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Article
Management of type 1 diabetes in primary schools in Ireland: a cross-sectional survey
Parents reported experiences of support for diabetes management in schools are variable. Recent data from European countries are sparse and experiences in the Irish primary school setting have not been describ...
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Physical activity and mental health in an Irish population
Physical activity represents a modifiable behaviour which may be associated with increased likelihood of experiencing positive mental health.
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Reproductive ageing—turning back the clock?
Unintended childlessness is a distressing, and often unintended, consequence of delayed childbearing and reproductive ageing. The average maternal age at first birth has risen steadily in many industrialised c...
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Open AccessShort stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene
Hypoparathyroidism in children is a heterogeneous group with diverse genetic etiologies. To aid clinicians in the investigation and management of children with hypoparathyroidism, we describe the phenotype of ...
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Article
Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a...
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Family Communication of Genetic Risk: A Personalized Approach
Genetic information is changing the practice of medicine by personalizing prevention and treatment decisions based on the genetic profile of the individual. The impact of personalized genetic-based medicine ex...
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Open AccessEctopic expression of a small cell lung cancer transcription factor, INSM1 impairs alveologenesis in lung development
Insulinoma associated-1 (INSM1) gene is expressed exclusively in early embryonic neuroendocrine tissues, but has been found highly re-activated in most of the neuroendocrine tumors including small cell lung carci...
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Open AccessTeaching basic lung isolation skills on human anatomy simulator: attainment and retention of lung isolation skills
Lung isolation skills, such as correct insertion of double lumen endobronchial tube and bronchial blocker, are essential in anesthesia training; however, how to teach novices these skills is underexplored. Our...
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Open AccessCoenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress
Coenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity ...
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Article
Sex, Race, and the Adverse Effects of Social Stigma vs. Other Quality of Life Factors Among Primary Care Patients with Moderate to Severe Obesity
Patients with obesity face widespread social bias, but the importance of this social stigma to patients relative to other quality of life (QOL) factors is unclear.
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Open AccessIs inflammatory chronic obstructive pulmonary disease a coronary heart disease risk equivalent? A longitudinal analysis of the third National Health and Nutrition Examination Survey (NHANES III), 1988–1994
Evidence suggests that there is an association between chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). An important etiological link between COPD and CHD may be an underlying sys...
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Open AccessEfficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy
The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmo...
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Open AccessAn Open-Label Investigation of the Pharmacokinetic Profiles of Lisdexamfetamine Dimesylate and Venlafaxine Extended-Release, Administered Alone and in Combination, in Healthy Adults
Lisdexamfetamine dimesylate (LDX), a prodrug consisting of d-amphetamine and l-lysine, is being studied in clinical trials of major depressive disorder. Additional drug-drug interaction studies were warranted.
