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Chapter
Cyclin A: Function and expression during cell proliferation
Cyclin A is a key regulatory protein which, in mammalian cells, is involved in both S phase and the G2/M transition of the cell cycle through its association with distinct cdks. Several lines of evidence have ...
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Article
Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
In higher eukaryotes, cell cycle progression is controlled by cyclin dependent kinases (Cdks) complexed with cyclins. A-type cyclins are involved at both G1/S and G2/M transitions of the cell cycle. Cyclin A2 ...
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Article
Correction: Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
Nature Genet. 15, 83–86 (1997). Maternally derived cyclin A2 was suggested to ensure normal cell division cycles in Ccna2–/– mouse embryos. This hypothesis was based on immunofluorescence studies at the blasto...
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Article
Comparison of clips versus sutures in orthopaedic wound closure
A prospective randomised trial was conducted to compare the use of skin clips versus interrupted nylon sutures in uncomplicated orthopaedic wound closure. Non-blinded wound assessment for complications and out...
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Article
Assessment of variation in position of the leg during follow-up total hip replacement (THR) radiographs
Standardised radiographs post total hip replacement (THR) have been shown to be vitally important in the accurate assessment of stem migration. We aimed to review radiographs at our institution to assess the r...
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Chapter
Towards Quality as an Equity Imperative
Improving access to education, globally, has been a key success of the Education for All movement, with an additional 50 million children enrolled in schooling since 2000 in sub-Saharan Africa alone (UNESCO, 2...
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Article
Open AccessLaboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America
Effective control of tick infestations on dogs is important to reduce the risk of transmission of bacterial, viral, and protozoal pathogens. Laboratory studies were initiated to determine the efficacy of lotil...
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Article
Open AccessAssessment of the onset of lotilaner (Credelio™) speed of kill of fleas on dogs
Lotilaner (Credelio™) is the newest member of the novel isoxazoline chemical class to be developed to treat canine ectoparasitism. Administered orally, lotilaner is rapidly absorbed with peak blood levels occu...
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Article
Open AccessLaboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs
With the geographical expansion of tick species and increased recognition of pathogens they transmit, there is a requirement for safe and rapidly effective control measures for dogs. Lotilaner, a novel isoxazo...
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Article
Open AccessLaboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio™) against three common species of ticks affecting dogs in Europe
There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy ...
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Article
Open AccessAssessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs
Lotilaner (Credelio™, Elanco), a novel isoxazoline, is a systemic insecticide and acaricide that is rapidly absorbed following oral administration to dogs and has a half-life of 30 days. As part of a developme...
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Article
Open AccessTwo randomized, controlled studies to assess the efficacy and safety of lotilaner (Credelio™) in preventing Dermacentor reticulatus transmission of Babesia canis to dogs
Dogs worldwide are at risk of Babesia spp. infections. Preventive efficacy of lotilaner tablets (Credelio™, Elanco) against Babesia canis was evaluated in two studies.
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Article
Open AccessA randomized, controlled study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned dogs in Europe
Oral administration of lotilaner flavoured chewable tablets (Credelio™, Elanco) to dogs has been shown to provide a rapid onset of killing activity of infesting ticks, with sustained efficacy for at least 35 d...
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Article
Open AccessA randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries
Lotilaner is a novel isoxazoline developed for oral administration to dogs. In laboratory studies, lotilaner was shown to be safe and to produce a rapid flea and tick knockdown, with a sustained speed of kill ...
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Article
Open AccessA randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™) in eliminating fleas in client-owned dogs in the USA
Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month pos...
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Article
Open AccessA randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe
Lotilaner is a new isoxazoline developed as an oral ectoparasiticide for cats and dogs. Its safety, rapid killing onset of action and sustained speed of fleas and ticks kill for a minimum of one month after ad...
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Article
Open AccessA randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe
There is a continuing need for novel approaches to tick infestations treatment and control in cats. Lotilaner, an isoxazoline with rapid onset of action, has proven its efficacy against ticks in laboratory stu...
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Article
Open AccessLaboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats
Lotilaner is approved for dogs as a chewable tablet formulation. It has separately been developed for oral administration in cats (Credelio™ chewable tablets for cats) to meet the need for an easy to use, safe...
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Article
Open AccessLaboratory evaluation of the efficacy and speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on cats
Lotilaner, approved for dogs as a chewable tablet formulation, has separately been developed for oral use in cats (CredelioTM chewable tablets for cats), to meet the need for an easy to use, safe and rapidly effe...
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Article
Open AccessLaboratory evaluation of the efficacy of lotilaner (Credelio™) against Haemaphysalis longicornis infestations of dogs
Throughout Japan, Korea and China, Haemaphysalis longicornis ticks are vectors of Babesia gibsoni, which causes severe and progressive anemia in dogs. This study evaluated the efficacy of a single administration ...
