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  1. Article

    Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats

    3,4-Methylenedioxy-N-methylcathinone (methylone) is a new psychoactive substance and the β-keto analog of 3,4-methylenedioxy-N-methylamphetamine (MDMA). It is well established that MDMA metabolism produces bioact...

    Joshua S Elmore, Ora Dillon-Carter, John S Partilla… in Neuropsychopharmacology (2017)

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  2. Article

    Open Access

    4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

    Novel psychoactive substances are continuously developed to circumvent legislative and regulatory efforts. A new synthetic cathinone, 4-methoxy-α-PVP, was identified for the first time in illegal products; how...

    Kayla N. Ellefsen, Ariane Wohlfarth, Madeleine J. Swortwood… in Forensic Toxicology (2016)

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    Article

    Simultaneous plasma and oral fluid morphine and codeine concentrations after controlled administration of poppy seeds with known opiate content

    Opiates are included in drug testing programs because of their psychoactive properties and abuse potential, but excluding poppy seed ingestion is necessary to correctly interpret positive opiate results. There...

    Matthew N. Newmeyer, Marta Concheiro, Jose Luiz da Costa… in Forensic Toxicology (2015)

  4. No Access

    Article

    Quantification of methylone and metabolites in rat and human plasma by liquid chromatography-tandem mass spectrometry

    Methylone is a commonly abused synthetic cathinone derivative marketed as a “legal” alternative to “ecstasy” or cocaine. Previous studies examined the metabolism of methylone in vitro and in vivo; 4-hydroxy-3-...

    Kayla N. Ellefsen, Marta Concheiro, Masaki Suzuki, Kenner C. Rice… in Forensic Toxicology (2015)

  5. Article

    The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study

    Extensive preclinical data implicate corticotropin-releasing hormone (CRH), acting through its CRH1 receptor, in stress- and dependence-induced alcohol seeking. We evaluated pexacerfont, an orally available, b...

    Laura E Kwako, Primavera A Spagnolo, Melanie L Schwandt… in Neuropsychopharmacology (2015)

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    Article

    Hair analysis interpretation of an unusual case of alleged scopolamine-facilitated sexual assault

    The apparent victim in an alleged scopolamine-facilitated sexual assault case requested a toxicological hair analysis. Hair decontamination wash solvents were evaporated and stored until analysis. Hair was inc...

    Ana de Castro, Elena Lendoiro, Óscar Quintela, Marta Concheiro… in Forensic Toxicology (2012)