24 Result(s)
within
Markus Guba
English
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Article
Open AccessRegional transplant rates depend more on physician-dependent variables than on proximity to transplant center
The objective of this work was to uncover inequalities in access to liver transplantation in Bavaria, Germany.
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Article
Open AccessNeutrophil extracellular traps facilitate cancer metastasis: cellular mechanisms and therapeutic strategies
The formation of neutrophil extracellular traps (NETs) was initially discovered as a novel immune response against pathogens. Recent studies have also suggested that NETs play an important role in tumor progre...
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Article
Open AccessThe transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics
Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of...
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Article
Technical Aspects of Orthotopic Liver Transplantation—a Survey-Based Study Within the Eurotransplant, Swisstransplant, Scandiatransplant, and British Transplantation Society Networks
Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. However, technical aspects of OLT are still subject of ongoing debate and are widely based on person...
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Article
Open AccessOnset and progression of diabetes in kidney transplant patients receiving everolimus or cyclosporine therapy: an analysis of two randomized, multicenter trials
Conversion from calcineurin inhibitor (CNI) therapy to a mammalian target of rapamycin (mTOR) inhibitor following kidney transplantation may help to preserve graft function. Data are sparse, however, concernin...
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Article
Open AccessExtra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer
Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like...
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Open AccessBenefit in liver transplantation: a survey among medical staff, patients, medical students and non-medical university staff and students
The allocation of any scarce health care resource, especially a lifesaving resource, can create profound ethical and legal challenges. Liver transplant allocation currently is based upon urgency, a sickest-fir...
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Article
Temporary Intraoperative Porto-Caval Shunts in Piggy-Back Liver Transplantation Reduce Intraoperative Blood Loss and Improve Postoperative Transaminases and Renal Function: A Meta-Analysis
The value of temporary intraoperative porto-caval shunts (TPCS) in cava-sparing liver transplantation is discussed controversially. Aim of this meta-analysis was to analyze the impact of temporary intraoperati...
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Article
Open AccessAutologous temporomandibular joint reconstruction independent of exogenous additives: a proof-of-concept study for guided self-generation
Joint defects are complex and difficult to reconstruct. By exploiting the body’s own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint rec...
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Article
Liver Resection for Non-colorectal Non-neuroendocrine Metastases: Where Do We Stand Today Compared to Colorectal Cancer?
The continuing controversy about surgery for non-colorectal non-neuroendocrine liver metastases (NCRNNE) necessitates identifying risk factors of worsened outcomes to improve patient selection and survival. Pr...
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Article
Rescue management of early complications after liver transplantation—key for the long-term success
Postoperative complications may have not only immediate but also long-term effects on the outcomes. Here, we analyzed the effect of postoperative complications requiring a reoperation (grade 3b) within the fir...
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Article
Open AccessEn-bloc resection of a giant retroperitoneal lipoma: a case report and review of the literature
Retroperitoneal lipomas are an extremely rare condition with only 17 cases described in the literature since 1980. They can reach enormous size and cause significant abdominal symptoms. The most important diff...
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Article
Open AccessUse of drug-eluting balloon coronary intervention prior to living donor kidney transplantation
Kidney transplantation is the gold standard of therapy in patients with terminal renal insufficiency. Living donor transplantation is a well-established option in this field. Enlarging the donor’s pool implica...
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Article
Open AccessCenter volume, competition, and outcome in German liver transplant centers
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Article
Open AccessExtended pancreas donor program – the EXPAND study rationale and study protocol
Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenil...
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Article
Impact of surgical training and surgeon’s experience on early outcome in kidney transplantation
The purpose of this study was to assess the impact of surgical training and surgeon’s experience on surgical quality and early outcome parameters.
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Article
Open Access99mTc-MAG3 scintigraphy for the longitudinal follow-up of kidney function in a mouse model of renal ischemia-reperfusion injury
Experimental models are essential tools in the development and evaluation of novel treatment options, but the preclinical model of renal ischemia-reperfusion injury is limited to the retrieval of (very) early ...
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Chapter
mTOR Signaling in Angiogenesis
An important feature of tumor blood vessels is that they are in a state of constant new tumor blood vessel growth. In endothelial cells, the PI3K/Akt pathway has been shown to play an important role in mediati...
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Article
Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis
The mammalian target of rapamycin (mTOR) is a controller of cell growth with multiple effects on cancer development and progression. Being closely linked to key oncogenic pathways that regulate tumor cell grow...
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Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer
Tumor angiogenesis is a process that requires migration, proliferation, and differentiation of endothelial cells. We hypothesized that decrease in pancreatic tumor growth due to inhibition of Src activity is a...
