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Article
Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis
Human malignant gliomas exhibit acquisition of either one of two telomere maintenance mechanisms, resulting from either reactivation of telomerase expression or activation of an alternative lengthening of telo...
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Article
Site-directed integration of transgenes: transposons revisited using DNA-binding-domain technologies
In the last 20 years, tools derived from DNA transposons have made major contributions to genetic studies from gene delivery to gene discovery. Various complementary and fairly ubiquitous DNA vehicles have bee...
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Article
Target site selection by the mariner-like element, Mos1
The eukaryotic transposon Mos1 is a class-II transposable element that moves using a “cut-and-paste” mechanism in which the transposase is the only protein factor required. The formation of the excision complex i...
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Article
Evolution of Full-Length and Deleted Forms of the Mariner-LikeElement, Botmar1, in the Genome of the Bumble Bee, Bombus terrestris (Hymenoptera: Apidae)
Mariner-like elements (MLE) are Class II transposable elements that are very widespread among eukaryotic genomes. One MLE belonging to the mauritiana subfamily, named Botmar1, has been identified in the genome of...
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Article
Features of the mammal mar1 transposons in the human, sheep, cow, and mouse genomes and implications for their evolution
Mariner-like elements (MLE) belong to the Tc1/mariner superfamily of class II transposons. We have analyzed the mariner related to the cecropia subfamily, and called mammal mar1, in four mammalian genomes, Bos t...