Page
%P
-
Article
Open AccessDesign and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasm...
-
Article
Open AccessA potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
To combat drug resistance, new chemical entities are urgently required for use in next generation anti-malarial combinations. We report here the results of a medicinal chemistry programme focused on an imidazo...
-
Article
Open AccessDiscovering antimalarials with a differential mode of action
-
Article
Open AccessCollaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets