4 Result(s)

Article

Discovering antimalarials with a differential mode of action

Laura Sanz, Maria Jose Lafuente, Sara Prats, Fernando Neria… in Malaria Journal (2014)

Article

Collaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets

Maria Jose Lafuente, Sonja Guidelli-Disse, Carolyn Selenski… in Malaria Journal (2014)

Article

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

To combat drug resistance, new chemical entities are urgently required for use in next generation anti-malarial combinations. We report here the results of a medicinal chemistry programme focused on an imidazo...

David A. Baker, Lindsay B. Stewart, Jonathan M. Large… in Nature Communications (2017)

Article

Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones

There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasm...

Robert D. Clark, Denise N. Morris… in Journal of Computer-Aided Molecular Design (2020)