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Chapter and Conference Paper
IGV-plus: A Java Software for the Analysis and Visualization of Next-Generation Sequencing Data
In this work we describe IGV-plus, a software for next-generation sequencing (NGS) data analysis and visualization. It integrates de facto standard tools for the discovery of genetic mutations in genomic-wide ass...
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Article
Open AccessHMGA1P7-pseudogene regulates H19 and Igf2 expression by a competitive endogenous RNA mechanism
Recent studies have revealed that pseudogene transcripts can function as competing endogenous RNAs, and thereby can also contribute to cancer when dysregulated. We have recently identified two pseudogenes, HMGA1P...
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Article
Open AccessmiR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene
Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing CBX7 as a tumor suppressor gene with a key role in cancer progression. This role ...
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Article
Open AccessHMGA1-pseudogene7 transgenic mice develop B cell lymphomas
We have recently identified and characterized two pseudogenes (HMGA1P6 and HMGA1P7) of the HMGA1 gene, which has a critical role in malignant cell transformation and cancer progression. HMGA1P6 and HMGAP17 act as...
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Article
Interplay between HMGA and TP53 in cell cycle control along tumor progression
The high mobility group A (HMGA) proteins are found to be aberrantly expressed in several tumors. Studies (in vitro and in vivo) have shown that HMGA protein overexpression has a causative role in carcinogenes...
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Article
Open AccessPublisher Correction: HMGA1-pseudogene7 transgenic mice develop B cell lymphomas
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Article
Open AccessThe lncRNA RMST is drastically downregulated in anaplastic thyroid carcinomas where exerts a tumor suppressor activity impairing epithelial-mesenchymal transition and stemness
Thyroid cancer is the most prevalent endocrine malignancy and comprises a wide range of lesions subdivided into differentiated (DTC) and undifferentiated thyroid cancer (UTC), mainly represented by the anaplas...
