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Open AccessAncient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval skeletons from Denmark that sho...
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Article
Open AccessTargeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genoty** of HLA genes in historical human populations
The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is c...