5 Result(s)
within
Manuela Moriggi
English
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Article
Open AccessGBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal storage Gaucher disease (GD) and are among the most frequent genetic risk factors for Parkinson’s disease (PD). So far, studies on both neu...
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Article
Open AccessAuthor Correction: Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight
The original version of this Article contained an error in the spelling of the author Claudio Franceschi, which was incorrectly given as Claudio Francheschi. This has now been corrected in both the PDF and HTM...
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Article
Open AccessSarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight
Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in or...
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Article
Open AccessTCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans
In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to...
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Article
Open AccessVibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest
Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health and fitness also of crew members in spaceflight. B...
