6 Result(s)
within
Manfred Rauh
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA pipeline for the fully automated estimation of continuous reference intervals using real-world data
Reference intervals are essential for interpreting laboratory test results. Continuous reference intervals precisely capture physiological age-specific dynamics that occur throughout life, and thus have the po...
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Article
Open AccessPharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia
In the treatment of childhood acute lymphoblastic leukemia (ALL), current protocols combine initial high-dose multiagent chemotherapy with prolonged oral therapy with 6-mercaptopurine (6MP) and low-dose methot...
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Article
Open AccessInfluence of Turkish origin on hematology reference intervals in the German population
Reference intervals for laboratory test results have to be appropriate for the population in which they are used to be clinically useful. While sex and age are established partitioning criteria, patients’ orig...
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Article
Open AccessrefineR: A Novel Algorithm for Reference Interval Estimation from Real-World Data
Reference intervals are essential for the interpretation of laboratory test results in medicine. We propose a novel indirect approach to estimate reference intervals from real-world data as an alternative to d...
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Article
Open AccessReference Interval Estimation from Mixed Distributions using Truncation Points and the Kolmogorov-Smirnov Distance (kosmic)
Appropriate reference intervals are essential when using laboratory test results to guide medical decisions. Conventional approaches for the establishment of reference intervals rely on large samples from heal...
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Article
Open AccessHistone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration
Malignant gliomas are characterized by neurodegenerative actions leading to the destruction of surrounding brain parenchyma. The disturbance in glutamate homeostasis caused by increased expression of the gluta...
