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Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

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  1. Article

    Open Access

    Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

    In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of ...

    Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis in Nature Communications (2017)

  2. Article

    Open Access

    An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

    The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver. To elucidate the underlying mechanism, here we report a method of cr...

    Sean M. Armour, Jarrett R. Remsberg, Manashree Damle in Nature Communications (2017)