2 Result(s)
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Manashree Damle
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessTumor-associated B-cells induce tumor heterogeneity and therapy resistance
In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of ...
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Article
Open AccessAn HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver. To elucidate the underlying mechanism, here we report a method of cr...
