11 Result(s)
within
Malcolm G. Dunlop
Biomedicine
Cancer Research
Epidemiology
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Article
Open AccessCirculating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation
To investigate the association between circulating 25-hydroxyvitamin D (25-OHD) and colorectal cancer (CRC) survival outcomes.
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Article
Open AccessDissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood.
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Article
Open AccessGenetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis
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Article
Open AccessPhenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank
Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations of observational studies.
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Article
Open AccessGenetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study
We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through chan...
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Article
Open AccessThe effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials
Low circulating vitamin D levels are associated with poor colorectal cancer (CRC) survival. We assess whether vitamin D supplementation improves CRC survival outcomes.
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Open AccessGenome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome
We conducted a genome-wide scan to identify non-synonymous SNPs (nsSNPs) that might influence survival after a diagnosis of colorectal cancer (CRC).
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Article
Open AccessErratum: Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
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Article
Open AccessEvidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
A substantial fraction of familial colorectal cancer (CRC) and polyposis heritability remains unexplained. This study aimed to identify predisposing loci in patients with these disorders.
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Article
Open AccessMendelian randomisation analysis strongly implicates adiposity with risk of develo** colorectal cancer
Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a...
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Article
Screening for exonic copy number mutations at MSH2 and MLH1 by MAPH
Background: Exonic deletions in MSH2 and MLH1 are significant contributors to the mutation spectrum in HNPCC, and heterozygous changes in exon copy number are not detected by conventional mutation screening metho...
