30 Result(s)

Article

Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation

To investigate the association between circulating 25-hydroxyvitamin D (25-OHD) and colorectal cancer (CRC) survival outcomes.

**aomeng Zhang, Yazhou He, Xue Li, Rasha Shraim, Wei Xu… in British Journal of Cancer (2024)

Article

Fine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...

Zhishan Chen, **ngyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law… in Nature Communications (2024)

Article

Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate th...

Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou… in Nature Communications (2024)

Article

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European a...

Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda… in Nature Communications (2023)

Article

Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk

Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood.

Xuan Zhou, Qian **ao, Fangyuan Jiang, **g Sun, Lijuan Wang… in British Journal of Cancer (2023)

Article

Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome

The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).

**g Sun, Jianhui Zhao, Fangyuan Jiang, Lijuan Wang, Qian **ao… in Genome Medicine (2023)

Article

Genetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis

Rachel H. Horton, Malcolm G. Dunlop, Richard S. Houlston… in British Journal of Cancer (2023)

Article

Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico

Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased colorectal cancer (CRC) risk, demonstrating eQTL eff...

Bradley T. Harris, Vidya Rajasekaran, James P. Blackmur… in Scientific Reports (2022)

Article

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA splicing as a key driver of t...

Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri… in Nature Communications (2022)

Article

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank

Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations of observational studies.

**aomeng Zhang, Xue Li, Yazhou He, Philip J. Law… in British Journal of Cancer (2022)

Article

Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study

We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through chan...

**aomeng Zhang, Evropi Theodoratou, Xue Li… in British Journal of Cancer (2021)

Article

The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials

Low circulating vitamin D levels are associated with poor colorectal cancer (CRC) survival. We assess whether vitamin D supplementation improves CRC survival outcomes.

Peter G. Vaughan-Shaw, Louis F. Buijs, James P. Blackmur… in British Journal of Cancer (2020)

Article

Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies

There is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such ...

Wei Xu, Yazhou He, Yuming Wang, Xue Li, Jane Young, John P. A. Ioannidis… in BMC Medicine (2020)

Article

Flexible and scalable diagnostic filtering of genomic variants using G2P with Ensembl VEP

We aimed to develop an efficient, flexible and scalable approach to diagnostic genome-wide sequence analysis of genetically heterogeneous clinical presentations. Here we present G2P (www.ebi.ac...

Anja Thormann, Mihail Halachev, William McLaren, David J. Moore… in Nature Communications (2019)

Article

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ...

Philip J. Law, Maria Timofeeva, Ceres Fernandez-Rozadilla… in Nature Communications (2019)

Article

Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome

We conducted a genome-wide scan to identify non-synonymous SNPs (nsSNPs) that might influence survival after a diagnosis of colorectal cancer (CRC).

Evropi Theodoratou, Susan M Farrington, Maria Timofeeva… in British Journal of Cancer (2018)

Article

Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vit...

Yazhou He, Maria Timofeeva, Susan M. Farrington, Peter Vaughan-Shaw… in BMC Medicine (2018)

Article

Plasma N-glycans in colorectal cancer risk

Aberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasma N-glycosylation between colorectal cancer (CRC) cases and controls in one of...

Margaret Doherty, Evropi Theodoratou, Ian Walsh, Barbara Adamczyk… in Scientific Reports (2018)

Article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (

**a Jiang, Paul F. O’Reilly, Hugues Aschard, Yi-Hsiang Hsu… in Nature Communications (2018)

Article

Erratum: Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia

Stephanie A Schubert, Dina Ruano, Fadwa A Elsayed, Arnoud Boot… in British Journal of Cancer (2018)