7 Result(s)
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Article
Open AccessRisk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies
There is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such ...
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Article
Open AccessExploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study
Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vit...
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Chapter
Polyposis Syndromes and Colorectal Cancer Predisposition
Colorectal polyps are common, affecting 25% of the population by age 75 years. However, the presence of multiple polyps, particularly in association with a personal or family history of colorectal cancer, shou...
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Article
Molecular genetics in gastroenterology: from research success to clinical application?
Advances in molecular genetics have aided our understanding of disease pathogenesis and have helped in making therapeutic decisions. Knowledge is still evolving, however, and care must be taken in extrapolatin...
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Article
Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue
Repetitive tracts within the coding regions of TGFBR2 and BAX are frequently mutated in mismatch repair deficient tumours and are implicated in tumour progression. However, there has been little study of the bala...
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Article
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes
Colorectal cancer has been described in terms of genetic instability selectively affecting either microsatellite sequences (MIN) or chromosome number and structure (CIN). A subgroup with apparently stable, nea...
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Chapter
The genetics of familial colon cancer
In developed countries, colorectal cancer is the second most common cause of death due to malignancy after lung cancer in males and third most common after lung and breast cancer in females. In the UK this man...
