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    Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks

    Regulatory loops between transcriptional activators and repressors control the circadian clock. A minimal synthetic combination of these transcription factors is sufficient to drive a robust circadian rhythm.

    Maki Ukai-Tadenuma, Takeya Kasukawa, Hiroki R. Ueda in Nature Cell Biology (2008)