8 Result(s)

Article

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like ...

Tesa M. Severson, Denise M. Wolf, Christina Yau, Justine Peeters… in Breast Cancer Research (2017)

Article

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

Although large-scale efforts for molecular profiling of cancer samples provide multiple data types for many samples, most approaches for finding candidate cancer genes rely on somatic mutations and DNA copy nu...

Andreas Schlicker, Magali Michaut, Rubayte Rahman… in Scientific Reports (2016)

Article

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular...

Magali Michaut, Suet-Feung Chin, Ian Majewski, Tesa M. Severson… in Scientific Reports (2016)

Article

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for...

Esther H. Lips, Magali Michaut, Marlous Hoogstraat… in Breast Cancer Research (2015)

Article

Bringing order to protein disorder through comparative genomics and genetic interactions

Intrinsically disordered regions are widespread, especially in proteomes of higher eukaryotes. Recently, protein disorder has been associated with a wide variety of cellular processes and has been implicated i...

Jeremy Bellay, Sangjo Han, Magali Michaut, TaeHyung Kim, Michael Costanzo… in Genome Biology (2011)

Article

Highlights from the 6th International Society for Computational Biology Student Council Symposium at the 18th Annual International Conference on Intelligent Systems for Molecular Biology

This meeting report gives an overview of the keynote lectures and a selection of the student oral and poster presentations at the 6th International Society for Computational Biology Student Council Symposium t...

Christiaan Klijn, Magali Michaut, Thomas Abeel in BMC Bioinformatics (2010)

Article

InteroPORC: an automated tool to predict highly conserved protein interaction networks

Magali Michaut, Samuel Kerrien, Luisa Montecchi-Palazzi… in BMC Bioinformatics (2008)

Article

Cadmium triggers an integrated reprogramming of the metabolism of Synechocystis PCC6803, under the control of the Slr1738 regulator

Cadmium is a persistent pollutant that threatens most biological organisms, including cyanobacteria that support a large part of the biosphere. Using a multifaceted approach, we have investigated the global re...

Laetitia Houot, Martin Floutier, Benoit Marteyn, Magali Michaut… in BMC Genomics (2007)