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  1. Article

    Open Access

    The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

    Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like ...

    Tesa M. Severson, Denise M. Wolf, Christina Yau, Justine Peeters… in Breast Cancer Research (2017)

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  2. Article

    Open Access

    Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

    In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for...

    Esther H. Lips, Magali Michaut, Marlous Hoogstraat… in Breast Cancer Research (2015)

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