10 Result(s)
within
M.-L. Rao
English
Psychiatry
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Article
Stability of serum neuroleptic and prolactin concentrations during short- and long-term treatment of schizophrenic patients
The potential importance of neuroleptic activity measures in the management of schizophrenia warrants attention to the methods for assessing neuroleptic bioactivity and stability of neuroleptic bioactivity ove...
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Article
Concurrence of cortex and platelet serotonin2 receptor binding characteristics in the individual and the putative regulation by serotonin
Changes in the central and peripheral serotonergic receptor activity have been reported to be involved in depression and suicidality. To elucidate the interdependence between central and peripheral receptor si...
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Article
Abstracts Second Congress of the European Society for Clinical Neuropharmacology
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Chapter and Conference Paper
Negative Symptoms of Schizophrenia: Methodological Issues, Biochemical Findings and Efficacy of Neuroleptic Treatment
Negative symptoms (minus symptoms) are defined increasingly as a focus of interest both for etiopathogenetic research and psychopharmacological research. However, the findings in both areas are often contradic...
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Article
Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease
Bleomycin hydrolase (BH), a cysteine protease from the papain superfamily, is considered to be a candidate for the β-secretase, which is presumably involved in the production of β-amyloid peptide. The G/G geno...
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Article
Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17β
24-Hydroxycholesterol, the main cholesterol elimination product of the brain is increased in serum of Alzheimer patients. This oxysterol behaves neurotoxic towards the human neuroblastoma cell line, SH-SY5Y. ...
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Article
Initial serotonin transport into viable platelets and imipramine binding to platelet membranes
Transport of serotonin into human platelets is a paradigm for neuronal reuptake to investigate putatively low neurotransmitter availability in certain psychiatric diseases. However, inconsistent results have ...
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Article
The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study
Insulin (INS) and insulin-like growth factors include different polypeptides involved in growth and development. Possibly they play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer'...
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Article
Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
Cholesterol and 24S-hydroxycholesterol are involved in the pathogenesis of Alzheimer's disease (AD). Increased serum cholesterol concentrations have been detected in patients with AD. 24S-Hydroxycholesterol is...
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Article
Polymorphism in the peroxisome proliferator-activated receptor α gene influences the risk for Alzheimer’s disease
The peroxisome proliferator-activated receptor α (PPAR-α) is a member of the steroid hormone super family of ligand-inducible transcription factors, involved in glucose and lipid metabolism. We screened for p...
