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  1. Article

    Open Access

    Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

    A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are...

    M. Schouten, P. Bielefeld, L. Garcia-Corzo, E. M. J. Passchier in Molecular Psychiatry (2020)

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    Article

    Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior

    Glucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a process that has been implicated in cognitive aspects of psychopathology, amongst others. Yet, the exact role of the GC rece...

    C P Fitzsimons, L W A van Hooijdonk, M Schouten, I Zalachoras in Molecular Psychiatry (2013)