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  1. Article

    Open Access

    Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients

    The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised older patients may show significant variation, from mild to severe illne...

    M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza… in Immunity & Ageing (2022)

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  2. No Access

    Article

    In vitro activity and in vivo efficacy of tigecycline alone and in combination with daptomycin and rifampin against Gram-positive cocci isolated from surgical wound infection

    The aim of this work was to determine the in vitro activity of tigecycline and its bactericidal effect for a large number of Gram-positive cocci, as well as to investigate its in vitro interaction with six cli...

    C. Silvestri, O. Cirioni, D. Arzeni… in European Journal of Clinical Microbiology … (2012)

  3. No Access

    Article

    Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma

    DNA vaccination against HER-2/neu is an effective way to induce an immune response able to oppose the spontaneous development of mammary tumours occurring in HER-2/neu transgenic mice. In this study, we have e...

    A Smorlesi, F Papalini, F Orlando, A Donnini, F Re, M Provinciali in Gene Therapy (2005)

  4. No Access

    Article

    DNA vaccination with full-length or truncated Neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice

    Genetic immunization against tumor antigens is an effective way to induce an immune response able to oppose cancer progression. Overexpression of HER-2/neu can lead to neoplastic transformation and has been fo...

    A Amici, A Smorlesi, G Noce, G Santoni, P Cappelletti, L Capparuccia… in Gene Therapy (2000)

  5. No Access

    Article

    Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice

    Numerous studies have demonstrated the efficacy of cytokine gene-engineered tumor cells to induce tumor rejection and specific memory acquisition into syngeneic immunocompetent mice by activation of host-depen...

    M Provinciali, K Argentati, A Tibaldi in Gene Therapy (2000)

  6. No Access

    Chapter

    Influence of Lymphokines and Thyroid Hormones on Natural Killer Activity

    Natural Killer (NK) cells are a subpopulation of lymphocytes which have spontaneous cytotoxic activity against tumor cells, virus-infected cells, and some normal cells (Herberman, 1982).

    M. Provinciali, M. Muzzioli, N. Fabris in Thyroid Autoimmunity (1987)