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  1. Article

    Erratum to: Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells

    Amlan Chakraborty, Sutirtha Chakraborty… in Annals of Biomedical Engineering (2016)

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    Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells

    This study demonstrated the effects of the directionality of oscillatory wall shear stress (WSS) on proliferation and proatherogenic gene expression (I-CAM, E-Selectin, and IL-6) in the presence of inflammator...

    Amlan Chakraborty, Sutirtha Chakraborty… in Annals of Biomedical Engineering (2016)

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    Article

    Peristalsis with Oscillating Flow Resistance: A Mechanism for Periarterial Clearance of Amyloid Beta from the Brain

    Alzheimer’s disease is characterized by accumulation of amyloid-β (Aβ) in the brain and in the walls of cerebral arteries. The focus of this work is on clearance of Aβ along artery walls, the failure of which may...

    M. Keith Sharp, Alexandra K. Diem, Roy O. Weller… in Annals of Biomedical Engineering (2016)

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    Article

    Simulated Stand Tests and Centrifuge Training to Prevent Orthostatic Intolerance on Earth, Moon, and Mars

    One proposed method to overcome postflight orthostatic intolerance is for astronauts to undergo inflight centrifugation. Cardiovascular responses were compared between centrifuge and gravitational conditions u...

    Brandon W. Coats, M. Keith Sharp in Annals of Biomedical Engineering (2010)

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    Chapter and Conference Paper

    Computationally Determined Shear on Cells Grown in Orbiting Culture Dishes

    A new computational model, using computational fluid dynamics (CFD), is presented that describes fluid behavior in cylindrical cell culture dishes resulting from motion imparted by an orbital shaker apparatus....

    R. Eric Berson, Matthew R. Purcell, M. Keith Sharp in Oxygen Transport to Tissue XXIX (2008)

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    Article

    Evaluation of Mechanisms of Postflight Orthostatic Intolerance with a Simple Cardiovascular System Model

    A significant fraction of astronauts experience postflight orthostatic intolerance (POI) during 10-min stand tests conducted on landing day. The average time that nonfinishers can stand is about 7 min. This ph...

    Justin Broskey, M. Keith Sharp in Annals of Biomedical Engineering (2007)

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    Article

    Numerical Simulation of the Influence of Gravity and Posture on Cardiac Performance

    A numerical model of the cardiovascular system was used to quantify the influences on cardiac function of intrathoracic pressure and intravascular and intraventricular hydrostatic pressure, which are fundament...

    Kristy Peterson, Edwin T. Ozawa, George M. Pantalos… in Annals of Biomedical Engineering (2002)

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    Article

    Influence of Gravity on Cardiac Performance

    Results obtained by the investigators in ground-based experiments and in two parabolic flight series of tests aboard the NASA KC-135 aircraft with a hydraulic simulator of the human systemic circulation have c...

    George M. Pantalos, M. Keith Sharp, Stewart J. Woodruff… in Annals of Biomedical Engineering (1998)

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    Article

    Scaling of Hemolysis in Needles and Catheters

    Hemolysis in clinical blood samples leads to inaccurate assay results and often to the need for repeated blood draws. In vitro experiments were conducted to determine the influence on hemolysis in phlebotomy need...

    M. Keith Sharp, S. Fazal Mohammad in Annals of Biomedical Engineering (1998)

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    Article

    Shear-augmented dispersion in non-Newtonian fluids

    The rate of spread of a passive species is modified by the superposition of a velocity gradient on the concentration field. Taylor (18) solved for the rate of axial dispersion in fully developed steady Newtoni...

    M. Keith Sharp in Annals of Biomedical Engineering (1993)