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Article
Open AccessNo topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan
CPT-11 (irinotecan) is a DNA-topoisomerase I inhibitor with preclinical activity against neuroblastoma (NB) xenografts. The aim was to establish in vivo an NB xenograft resistant to CPT-11 in order to study the r...
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Article
Open AccessBilateral germ-cell tumours: 22-year experience at the Institut Gustave Roussy
The aim of this study was to describe the incidence, clinical and histological characteristics, treatment and long-term follow-up of bilateral germ-cell tumours (BGCT) of the testis in order to determine in wh...
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Article
Open AccessComparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
A series of 23 children with primitive neuroectodermal tumours (PNET) were analysed with comparative genomic hybridization (CGH). Multiple chromosomal imbalances have been detected in 20 patients. The most fre...
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Article
Open AccessBusulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations
High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing’s sarcoma and medulloblastoma. However, the anti-tumour activity...