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Chapter
Resistance of Brain Tumours to Chemotherapy: Preliminary Studies of Rat and Human Tumours
There are several possible reasons why malignant brain tumours do not respond to chemotherapy. First, because of impaired drug delivery, chemotherapeutic agents might not reach all tumour cells in cytoxic conc...
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Chapter
Centrocytic Lymphoma: a B-Cell Non-Hodgkin’s Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements
Centrocytic lymphoma is a CD5-positive B cell neoplasm defined in the Kiel classification (Figure 1) [1]. This lymphoma, composed of cells resembling centrocytes (cleaved follicular center cells), is distingui...
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Article
The routine use of diagnostic laparoscopy in the intensive care unit
Background: Delay in the diagnosis of intraabdominal pathology is a major contributor to the morbidity and mortality of intensive care unit (ICU) patients. Laparoscopy is a valuable diagnostic tool that can be...
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Article
Open AccessCombinatorial drug screening identifies synergistic co-targeting of Bruton’s tyrosine kinase and the proteasome in mantle cell lymphoma