450 Result(s)

Article

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically describ...

Liang Chen, Haotong Li, **aorui Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation

The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning ...

Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl… in Bone Marrow Transplantation (2024)

Article

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necess...

Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono… in Oncogenesis (2024)

Article

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essent...

Bonan Chen, Peiyao Yu, Wai Nok Chan, Fuda **e… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1

L. Venturutti, R. I. Cordo Russo, M. A. Rivas, M. F. Mercogliano, F. Izzo… in Oncogene (2023)

Article

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs tha...

Chunsik Lee, Rongyuan Chen, Guangli Sun… in Signal Transduction and Targeted Therapy (2023)

Article

WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines

Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoti...

Leigh A. Bumpous, Kylie C. Moe, **g Wang, Logan A. Carver… in Oncogenesis (2023)

Article

Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party

Raffaella Greco, Jorinde D. Hoogenboom… in Bone Marrow Transplantation (2023)

Article

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been und...

Junhui Hu, ** Tan, Moe Ishihara… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but...

Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions

Exploring the relationship between various neurotransmitters and breast cancer cell growth has revealed their likely centrality to improving breast cancer treatment. Neurotransmitters play a key role in breast...

Priya Jayachandran, Francesca Battaglin, Carly Strelez, Annika Lenz… in Oncogene (2023)