539 Result(s)
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English
Medicine & Public Health
Internal Medicine
M. **gliang
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Article
Open AccessEfficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
The aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes inadequately controlled with metformin treatment.
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Open Access“Textbook outcome(s)” in colorectal surgery: a systematic review and meta-analysis
Textbook outcome (TO) is a composite measure used in surgery to evaluate post operative outcomes. No review has synthesised the evidence in relation to TO regarding the elements surgeons are utilising to infor...
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Open AccessSingle-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell glucotoxicity and subsequently type 2 diabetes. In this study, we explored the...
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Open AccessCorrection: Impact of non-pharmaceutical interventions during COVID-19 on future influenza trends in Mainland China
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Open AccessGadolinium-enhanced intracranial aneurysm wall imaging and risk of aneurysm growth and rupture: a multicentre longitudinal cohort study
In patients with an unruptured intracranial aneurysm, gadolinium enhancement of the aneurysm wall is associated with growth and rupture. However, most previous studies did not have a longitudinal design and di...
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Open AccessAssociation between COVID-19 convalescent plasma antibody levels and COVID-19 outcomes stratified by clinical status at presentation
There is a need to understand the relationship between COVID-19 Convalescent Plasma (CCP) anti-SARS-CoV-2 IgG levels and clinical outcomes to optimize CCP use. This study aims to evaluate the relationship betw...
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Open AccesseNAMPT is a novel therapeutic target for mitigation of coronary microvascular disease in type 2 diabetes
Individuals with diabetes are at high risk of cardiovascular complications, which significantly increase morbidity/mortality. Coronary microvascular disease (CMD) is recognised as a critical contributor to the...
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Open AccessSmart mandibular advancement devices for obstructive sleep apnea: a systematic literature review
The goal of this review is to provide sleep physicians, dentists, and researchers with an evidence-based overview of the literature on smart mandibular advancement devices (MADs) for the treatment of obstructi...
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Open AccessThe Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study
Testing the role of the Multidimensional Prognostic Index (MPI), based on the Comprehensive Geriatric Assessment (CGA), in predicting the risk of incident delirium in hospitalized older patients with COVID-19.
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Open AccessAnalysis of Top 100 Articles Cited in Top Pain Journals: A Comprehensive Two Decade Bibliometric Analysis
A bibliometric analysis was performed to analyze and compare the top 100 articles from the most well-known five pain journals: Pain, Pain Physician, Pain Medicine, Regional Anesthesia & Pain Medicine, and Journal...
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Open AccessFrailty as an Effect Modifier in Randomized Controlled Trials: A Systematic Review
The effect of clinical interventions may vary by patients’ frailty status. Understanding treatment effect heterogeneity by frailty could lead to frailty-guided treatment strategies and reduce overtreatment and...
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Open AccessUnderstanding Perspectives on Presbyopia and Use of Pilocarpine HCl 1.25% Twice Daily from Participants of the Phase 3 VIRGO Study
The phase 3, randomized, vehicle-controlled, 14-day VIRGO study evaluated the efficacy and safety of twice-daily dosing of pilocarpine hydrochloride ophthalmic solution 1.25% (Pilo) in presbyopia. On VIRGO exi...
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Open AccessClinico-pathological factors associated with radioiodine refractory differentiated thyroid carcinoma status
Risk factors for develo** radioiodine refractory thyroid cancer (RAIR-TC) have rarely been analyzed. The purpose of the present study was to find clinical and pathological features associated with the occurr...
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Open AccessEconomic Evaluation of Nirmatrelvir/Ritonavir Among Adults Against Hospitalization During the Omicron Dominated Period in Malaysia: A Real-World Evidence Perspective
Nirmatrelvir/ritonavir was administered orally to manage mild to moderate symptoms of COVID-19 in adult patients. The objectives of this study were to (i) evaluate the cost-effectiveness of prescribing nirmatr...
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Open AccessPolygenic risk scores for autoimmune related diseases are significantly different in cancer exceptional responders
A small number of cancer patients respond exceptionally well to therapies and survive significantly longer than patients with similar diagnoses. Profiling the germline genetic backgrounds of exceptional respon...
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Open AccessEffect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT
Emphysema influences the appearance of lung tissue in computed tomography (CT). We evaluated whether this affects lung nodule detection by artificial intelligence (AI) and human readers (HR).
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Open AccessMigraine or any headaches and white matter hyperintensities and their progression in women and men
Cross-sectional and longitudinal studies have been conducted to investigate the association between migraine and any headache and white matter hyperintensities (WMH). However, studies are inconsistent regardin...
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Open AccessAuthor Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
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Open AccessGermline findings in cancer predisposing genes from a small cohort of chordoma patients
Chordoma is a rare slow-growing tumor that occurs along the length of the spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet 75:335–336, 1998). Most chordomas are spora...
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Open AccessGlucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study
As the prevalence of insulin resistance and glucose intolerance is increasing throughout the world, diabetes-induced eye diseases are a global health burden. We aim to identify distinct optical bands which are...
