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  1. No Access

    Article

    Tryptophan metabolism along the kynurenine and serotonin pathways reveals substantial differences in colon and rectal cancer

    Induction of tryptophan (TRP) catabolism is an adaptation mechanism to restrict excessive acute immune response in tissues. In the tumour microenvironment, TRP catabolism’s dysregulation plays an important rol...

    S. Crotti, E. D’Angelo, C. Bedin, M. Fassan, S. Pucciarelli, D. Nitti… in Metabolomics (2017)

  2. Article

    Open Access

    Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

    Impairment of the immune response and aberrant expression of microRNAs are emerging hallmarks of tumour initiation/progression, in addition to driver gene mutations and epigenetic modifications. We performed a...

    T Colangelo, G Polcaro, P Ziccardi, B Pucci, L Muccillo, M Galgani… in Cell Death & Disease (2016)

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