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  1. Article

    Open Access

    Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

    Compounds targeting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are being investigated in multiple clinical settings, but drug resistance may reduce their benefit. Compoun...

    M Dermit, P Casado, V Rajeeve, E H Wilkes, D E Foxler, H Campbell, S Critchlow… in Oncogene (2017)

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