56 Result(s)

Article

High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk

Testing 1-h glucose (1HG) concentration during oral glucose tolerance test is cost-effective to identify individuals at risk of incident type 2 diabetes. Aim of the study was to define 1HG cutoffs diagnostic o...

L. Ravà, D. Fintini, M. Mariani, A. Deodati… in Journal of Endocrinological Investigation (2023)

Article

Multicentric Italian case–control study on 25OH vitamin D levels in children and adolescents with Prader-Willi syndrome

25OHD levels in patients with Prader-Willi Syndrome (PWS), the most frequent cause of genetic obesity with a peculiar fat mass distribution, are still debated. Insulin resistance (IR), Body Mass Index-SDS (BMI...

F. M. Panfili, A. Convertino, G. Grugni… in Journal of Endocrinological Investigation (2023)

Article

Appropriate management of growth hormone deficiency during the age of transition: an Italian Delphi consensus statement

S. Cannavò, M. Cappa, D. Ferone, A. M. Isidori… in Journal of Endocrinological Investigation (2023)

Article

Efficacy of short-term induction therapy with low-dose testosterone as a diagnostic tool in the workup of delayed growth and puberty in boys

Constitutional delay of growth and puberty (CDGP) represents the most frequent cause of delayed puberty in males, sharing some clinical features with growth hormone deficiency (GHD) and isolated hypogonadotrop...

S. Mastromattei, T. Todisco, L. Chioma… in Journal of Endocrinological Investigation (2022)

Article

MKRN3 circulating levels in Prader–Willi syndrome: a pilot study

Hypogonadism in Prader–Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect. MKRN3, a maternal imprinted gene located on 15q11.2-q13 region, encodes makorin ring f...

M. Mariani, D. Fintini, G. Cirillo, S. Palumbo… in Journal of Endocrinological Investigation (2022)

Article

Mechanisms of acute hypercalcemia in pediatric patients following the interruption of Denosumab

Denosumab is a fully human monoclonal anti-RANK-L antibody that is clinically used to counteract the bone loss induced by exacerbated osteoclast activity. Indeed, its binding to RANK-L prevents the interaction...

A. Deodati, D. Fintini, E. Levtchenko… in Journal of Endocrinological Investigation (2022)

Article

Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype

Multiple factors influence intrauterine growth and lead to low birth sizes. The impact of genetic alterations on both pre- and post-natal growth is still largely unknown. The aim of this study was to investiga...

E. Inzaghi, A. Deodati, S. Loddo, M. Mucciolo… in Journal of Endocrinological Investigation (2022)

Article

Exercise-induced GH secretion is related to puberty

Exercise represents a physiological stimulus that initiates the coordinated responses of hypothalamic–pituitary axis and sympathetic nervous system. Aims of the study were: 1) to analyze the response of GH, co...

C. Bizzarri, D. Colabianchi, G. A. Giannone… in Journal of Endocrinological Investigation (2021)

Article

Dihydrotestosterone (DHT) rapidly increase after maximal aerobic exercise in healthy males: the lowering effect of phosphodiesterase’s type 5 inhibitors on DHT response to exercise-related stress

Few data exist on dihydrotestosterone (DHT) adaptation to exercise-related stress. The aim of the study was to investigate on serum DHT and other androgens’ responses to acute aerobic exercises, and to verify ...

P. Sgrò, C. Minganti, M. Lista, C. Antinozzi… in Journal of Endocrinological Investigation (2021)

Article

Bilateral testicular masses and adrenal insufficiency: is congenital adrenal hyperplasia the only possible diagnosis? First two cases of TARTS described in Addison-only X-linked adrenoleukodystrophy and a brief review of literature

Testicular adrenal rest tumors (TARTs) are benign masses deemed to originate from pluripotent testicular steroidogenic cells that grow under chronic ACTH stimulation. These lesions, occasionally misdiagnosed a...

A. S. Tresoldi, N. Betella, V. Hasenmajer… in Journal of Endocrinological Investigation (2021)

Article

The use of prohibited substances for therapeutic reasons in athletes affected by endocrine diseases and disorders: the therapeutic use exemption (TUE) in clinical endocrinology

To protect sporting ethics and athletes’ health, the World Anti-Do** Agency (WADA) produced the World Anti-Do** Code and The Prohibited List of substances and methods forbidden in sports. In accordance wit...

L. Di Luigi, F. Pigozzi, P. Sgrò, L. Frati… in Journal of Endocrinological Investigation (2020)

Article

Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity

To evaluate the relationship between wrist circumference, markers of adipose dysfunction, and cardiovascular risk in youths with obesity.

C. Luordi, E. Maddaloni, C. Bizzarri… in Journal of Endocrinological Investigation (2020)

Article

25OH vitamin D levels in pediatric patients affected by Prader–Willi syndrome

Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader–Wil...

D. Fintini, S. Pedicelli, S. Bocchini… in Journal of Endocrinological Investigation (2018)

Article

Growth hormone treatment improves final height and nutritional status of children with chronic kidney disease and growth deceleration

Growth retardation is a common complication of chronic kidney disease (CKD) in children. Treatment with recombinant human growth hormone (rhGH) has been used to help short children with CKD to attain a height ...

C. Bizzarri, A. Lonero, M. Delvecchio… in Journal of Endocrinological Investigation (2018)